Background : Cadmium is a heavy metal having toxic effects on most organ\nsystems of the body. Objectives : We aim to investigate the postulated protective\nproperties of olive oil in Cadmium-induced renal toxicity in mice by utilizing\nstandard biomarkers of renal toxicity, oxidative stress and histopathological\ncharacterization. Materials and Methods : Forty mice were randomly\ndivided into four groups of 10 mice each. Group 1 served as control group,\ngroup 2 was given Extra-virgin olive oil orally, group 3 was given Cadmium\nchloride and group 4 was given Cadmium chloride with Extra-virgin olive oil.\nAt the end of the experimental period, biochemical analysis histopathology of\nkidney was done. Results : The present study depicted that blood urea, serum\ncreatinine and the antioxidant markers (Superoxide dismutase, Glutathione peroxidase\nand Catalase) levels were significantly increased in group 3 compared\nto group 1 and 2. After administration of Extra-virgin olive oil with Cadmium\nin group 4, the levels of those markers significantly improved. Histopathology\nof the renal tissue showed severe damage of glomeruli, severely congested blood\nvessels and marked dilatation of Bowman�s capsule in group 3 with improvements\nof these changes in group 4. Conclusion : This study suggests that Extra-\nvirgin olive oil can be used as a cost effective safe anti-oxidative agent in the\nprevention of Cadmium toxicity.
Loading....